Atherosclerosis (AS) is a chronic inflammatory disease characterized by the buildup of lipids and immune cells in arterial ...

A block in Mgm1 activity rapidly leads to mitochondrial fragmentation, mitochondrial aggregation and subsequent loss of mitochondrial DNA. Although these effects somewhat resemble the phenotype ...

Overloading of these systems leads to the accumulation of aggregates in the cytosol, the nucleus and the mitochondria. All the aggregation pathways converge towards the mitochondria and results in ...

Did you know that you have a second genome? Small cellular organelles called mitochondria contain their own circular DNA. What happens to your cells when this DNA mutates? Similar to the nuclear ...

Without functioning mitochondria, the cells become dysfunctional ... in large enough quantities to prevent large-scale ...

This dual action—targeting both protein aggregation and mitochondrial dysfunction—positions TFE3 as a promising therapeutic candidate for Parkinson's disease. By bolstering the brain's natural ...

The session, titled Detecting Mitochondrial Electron Transport Chain Enzyme Defects in Low-Heteroplasmy Single Large-Scale mtDNA Deletion Syndromes (SLSMDSs), was presented by Xueyang Pan ...