However, a gene mutation in the mitocondria's DNA, like the one caused by PolG, can impact the mitochondria and keep it from performing as it normally would. The disease could also impact a person ...

Mitochondria contain their own DNA which requires a specific enzyme to replicate, found in host cell’s POLG and POLG2 genes. Mutations in these genes therefore impact the ability for ...

according to the POLG Foundation. These mutations "compromise the functioning of the enzyme responsible for mitochondrial DNA ...

In people with POLG-related diseases, issues with polymerase gamma can either end up decreasing the amount of DNA in mitochondria or introducing mutations into that DNA. And in some cases ...

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease, a rare genetic disorder that he was born with, his family announced. Frederik de Nassau died in Paris on ...