POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury.

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

Two weeks after Prince Frederik of Luxembourg died from POLG, a documentary filmmaker has revealed that the 22-year-old ...

Polymerase gamma becomes a mutator polymerase, accelerating the accumulation of point mutations, frameshifts, and deletions in mitochondrial DNA. The steady accumulation of mutations is what accounts ...

What happens to your cells when this DNA mutates? Similar to the nuclear genome, the mitochondrial genome is built of double-stranded DNA, and it encodes genes (Figure 2). However, the ...

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease ... of a protein called polymerase gamma, according to the National Library of Medicine.

Summary of the effect of mammalian mtDNA on contributing 13 polypeptide subunits (PS) to five oxidative phosphorylation complexes (I–V) that make up the OXPHOS. The inner mitochondrial membrane ...

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant ...