This gene encodes a protein in mitochondria, called DNA polymerase gamma (pol γ), which is needed to replicate ... POLG mutations are the most common cause of inherited mitochondrial disorders, with ...

Polymerase gamma becomes a mutator polymerase, accelerating the accumulation of point mutations, frameshifts, and deletions in mitochondrial DNA. The steady accumulation of mutations is what accounts ...

Did you know that you have a second genome? Small cellular organelles called mitochondria contain their own circular DNA. What happens to your cells when this DNA mutates? Similar to the nuclear ...

The current findings indicate the importance of new mitochondrial functions in maintaining brain health." More information: Yilin Kang et al, Ancestral allele of DNA polymerase gamma modifies ...

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease, a rare genetic disorder that he was born with, his family announced. Frederik de Nassau died in Paris on ...

Two weeks after Prince Frederik of Luxembourg died from POLG, a documentary filmmaker has revealed that the 22-year-old struggled to "get up by himself" as he battled the rare genetic disorder in an ...

Research on mitochondrial DNA (mtDNA) reveals that the mitochondrial transcription elongation factor (TEFM) is crucial for maintaining the balance between mtDNA transcription and replication. TEFM ...

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury. This review sheds light on ...

Affected populations: POLG-related diseases are a group of rare, incurable conditions caused by inherited gene mutations. These disease-causing mutations are carried by up to 2% of people of ...