DISTRESSING footage of a shockingly obese panther at a Chinese zoo has sparked fury among animal lovers. The video captures ...

However, it has not been shown to be elevated in dietary obese animal models. In a study in mice, TNF-a-induced glycerol and fatty acid release was substantially reduced by a thiazolidinedione.

Leptin-sensitive animals showed no such dysregulation. "With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals," Tan says.

Our findings increased our knowledge of the link between inflammation and insulin resistance in non-obese animals, confirming that this is a key factor in diabetes even in the absence of obesity ...

"Our experiments involved Goto-Kakizaki [GK] rats, an animal model for non-obese type 2 diabetes. We found that insulin resistance can be reduced in these animals by modulating the inflammatory ...