Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer ...

Human endogenous retroviruses that colonized vertebrate DNA millions of ... more intact sequences from HERVs have been linked to disease. Around 8 percent of our genetic code stems from HERVs, the ...

In 1985, his group became the first to solve the structure ... including retroviruses and the Ebola virus. These proteins are responsible for binding and fusing the virus to target cell membranes.

Pre-clinical studies indicate that efficient retrovirus-mediated gene transfer into hematopoietic stem cells and progenitor cells can be achieved by co-localizing retroviral particles and target ...

A retrovirus is an infectious agent belonging ... upstream ORFs elicits distinct immune responses and regulates viral gene expression in a DDX3-dependent manner. HIV reservoir dynamics are still ...

HERVs share a basic structure with contemporary retroviruses ... Human Endogenous Retroviruses are not merely genetic fossils ...