Tens of millions of people across the central and southern US are at risk Tuesday of severe thunderstorms and tornadoes and fire weather on the storm’s warm side and blizzard conditions on its cold side.

Powerful storms that killed two people in Mississippi and ripped roofs from buildings in a small Oklahoma town are charging across the nation, threatening more communities in the central to eastern United States with wide-ranging weather.

The winter storm could impact up to 170 million people across more than 20 states from the southern Plains to the Midwest and East, AccuWeather said.