Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor ... CAR was detected in high abundance in DNA extracted from the patient’s duodenal-biopsy samples ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

Cancer is a perennial fear for therapies that involve altering DNA in cells ... said the latest analysis showed that the integration site of the vector was in a gene called VAMP4.

Recombinase efficiency increases allow Qi Biodesign to insert 20-30 kb (5 or 6 genes) at one time at one location across a variety of different crop genetics. In addition, a large team at Qi Biodesign ...

Monoclonal T cells from both patients had detectable CAR transgene expression and integration ... T-cell therapy that is produced by means of lentiviral transduction. In the phase 3, randomized ...

Researchers trial inhalable gene therapy for cystic fibrosis, offering a potential breakthrough in treating the genetic lung ...

AI-assisted AAV capsid engineering has transformative potential in terms of accelerating and optimizing the development of gene therapies.

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Large consortia-led projects such as ENCODE (Encyclopedia of DNA Elements) have made great strides in identifying various functional elements of the genome. These include enhancers, activators, and ...

This method of bacterial genome sequencing could be used to identify antibiotic-resistant strains—for example, in patients with urinary tract infections—or to locate beneficial strains in fecal ...