This gene encodes a protein in mitochondria, called DNA polymerase gamma (pol γ), which is needed to replicate ... POLG mutations are the most common cause of inherited mitochondrial disorders, with ...

Studies have identified that key proteins such as transcription factor A, mitochondrial (TFAM) and DNA polymerase gamma (POLG), both critical for mtDNA maintenance, are downregulated in I/R injury.

Polymerase gamma becomes a mutator polymerase, accelerating the accumulation of point mutations, frameshifts, and deletions in mitochondrial DNA. The steady accumulation of mutations is what accounts ...

What happens to your cells when this DNA mutates? Similar to the nuclear genome, the mitochondrial genome is built of double-stranded DNA, and it encodes genes (Figure 2). However, the ...

Estimates vary, but roughly one in 10,000 people are thought to have POLG, or polymerase gamma, disease, according to the United Mitochondrial ... organization used his DNA for research, initiated ...

Mitochondrial deoxyribonucleic acid (mtDNA ... finding of this study was the interaction between TEFM and the DNA polymerase γ (POLG), an essential enzyme involved in mtDNA replication.

Prince Frederik of Luxembourg has died at the age of 22 from POLG mitochondrial disease ... of a protein called polymerase gamma, according to the National Library of Medicine.

The current findings indicate the importance of new mitochondrial functions in maintaining brain health." More information: Yilin Kang et al, Ancestral allele of DNA polymerase gamma modifies ...

Two weeks after Prince Frederik of Luxembourg died from POLG, a documentary filmmaker has revealed that the 22-year-old struggled to "get up by himself" as he battled the rare genetic disorder in an ...

In people with POLG-related diseases, issues with polymerase gamma can either end up decreasing the amount of DNA in mitochondria ... common cause of inherited mitochondrial disorders, with ...