Studies have identified that key proteins such as transcription factor A, mitochondrial (TFAM) and DNA polymerase gamma (POLG), both critical for mtDNA maintenance, are downregulated in I/R injury.

Two weeks after Prince Frederik of Luxembourg died from POLG, a documentary filmmaker has revealed that the 22-year-old struggled to "get up by himself" as he battled the rare genetic disorder in an ...

Estimates vary, but roughly one in 10,000 people are thought to have POLG, or polymerase gamma, disease, according to the United Mitochondrial ... organization used his DNA for research, initiated ...

In people with POLG-related diseases, issues with polymerase gamma can either end up decreasing the amount of DNA in mitochondria ... common cause of inherited mitochondrial disorders, with ...

Estimates vary, but roughly one in 10,000 people are thought to have POLG, or polymerase gamma disease, according to the United Mitochondrial ... organisation used his DNA for research, initiated ...

Mitochondrial DNA (mtDNA) replication by the POLG-encoded mitochondrial DNA polymerase (POLG) is critical for mitochondrial health. Loss-of-function POLG variants are associated with a predisposition ...

Mitochondrial single stranded DNA-binding protein (mtSSB) exists as a stable tetramer and binds single-stranded DNA intermediates that form transiently during genome maintenance. DNA polymerase gamma ...

Background Large-scale mitochondrial DNA deletions (LMD ... similar to the network’s earlier studies on Leigh syndrome and polymerase gamma (POLG) related diseases.26 27 The data included family ...

Prince Frederik, the second cousin of the heir to the Luxembourg throne, discovered at age 14 that he had a mutation in his POLG gene, which is involved in the replication and repair of DNA ...