Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve ...

Purkinje cell (PC) hypoexcitability could play a role in Friedreich ataxia (FA) pathophysiology, according to a recently published study in The Cerebellum. Current research increasingly suggests that ...

Microglial turnover correlates with the Purkinje neuron loss in 2HIT mice. Highly multiplexed imaging-mass-cytometry identifies a cell transition to TREM2(+) stress-associated microglia in the ...

Currently, there appear to be three main cerebellar abnormalities observed in patients with ASD: diminished Purkinje cells, reduced cerebellar volume, and interrupted feedback pathways between the ...

A new study from the University of Maryland School of Medicine has found a possible link between inflammation during ...

Neuropathology in a presymptomatic case disclosed that Purkinje cells and hypoglossal neurons are affected. Conclusions SCA36 is rare with a worldwide distribution. It can be caused by a short GGCCTG ...

Mice lacking the secreted hormone, CTRP10, represent a unique female model of obesity with preserved metabolic health, highlighting sex-specific mechanisms that uncouple obesity from metabolic ...

Mar. 11, 2025 — Researchers have identified genetic changes in blood stem cells from frequent blood donors that support the production of new, non-cancerous cells. Understanding the differences ...