You may have heard of the fantastic-sounding "dark side of the genome." This poorly studied fraction of DNA, known as ...

Leveraging the power of AI and machine learning technologies, researchers at Weill Cornell Medicine developed a more ...

Affected populations: POLG-related diseases are a group of rare, incurable conditions caused by inherited gene mutations. These disease-causing mutations are carried by up to 2% of people of ...

Prince Frederik of Luxembourg, son of Prince Robert and Princess Julie of Nassau, passed away at 22 in Paris due to POLG mitochondrial disease. Diagnosed at 14, Frederik advocated for research and ...

POLG mitochondrial disease is a rare genetic disorder caused by mutations in the POLG gene, which plays a critical role in mitochondrial function. Mitochondria are responsible for generating energy in ...

It is a hereditary disorder caused by mutations in the POLG gene, which encodes an enzyme essential for mitochondrial DNA replication. In the case of Prince Federico, the disease manifested at the age ...

Mitochondria contain their own DNA which requires a specific enzyme to replicate, found in host cell’s POLG and POLG2 genes. Mutations in these genes therefore impact the ability for ...

POLG disease is caused by inherited mutations in the POLG gene, with more than 200 known disease-causing variants. These mutations impair the enzyme responsible for maintaining mitochondrial DNA ...

POLG disease is a mitochondrial disorder caused by mutations in the POLG gene. It typically affects multiple organs, primarily the brain, nerves, muscles, and liver, and can affect vision due to ...

PolG disease is a genetic disease caused by mutations that occur in the POLG gene in the mitochondria of a person's cell, according to the UMDF. It's one of the most commonly inherited ...

It is named for the POLG gene, and there are more than 200 POLG mutations that can cause the disease. The POLG Foundation described the disorder as robbing cells of energy and comparing it to a ...