SGOL1 knockout can reduce apoptosis and the cytotoxicity of sorafenib. The SGOL1 protein was disabled for the subsequent sister-chromatid segregation at inner centromeres (Zhang and Liu, 2020), ...

Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion. Figure 1 ...

In the absence of DDM1 and RNAi, this TE doesn’t produce small RNAs, so the centromere is not methylated. These mutants also ...

The most common abnormalities found were a variety of structural anomalies consisting of chromatid exchanges and chromatid and isochromatid breaks. Chromatid exchanges are abnormal chromosomal ...

(b) Spatial distribution of telomeres and centromeres of ten chromosomes in the 3D genome. The blue sphere indicates the telomeres, and the red sphere indicates centromeres. Each particle equals ...

Central to this process are microtubules, the mitotic spindle, centromeres, kinetochores, and mitotic checkpoints. Microtubules, components of the cytoskeleton, form the dynamic framework of the ...

This process occurs in two stages: meiosis I, in which homologous chromosomes are partitioned, and meiosis II, in which sister chromatid are segregated. The regulation of meiosis is crucial for ...

Centromeres are specific sites on chromosomes that are essential for mitosis and genome fidelity. This valuable work extends previous studies to convincingly show that the centromere-histone core ...

The study revealed the distinctive Bouquet configuration in both species, where telomeres cluster and centromeres are located at the nuclear periphery, offering vital insights into chromosome ...

Tumor cells show widespread genetic alterations that change the expression of genes driving tumor progression, including genes that maintain genomic integrity. In recent years, it has become clear ...