(b) Spatial distribution of telomeres and centromeres of ten chromosomes in the 3D genome. The blue sphere indicates the telomeres, and the red sphere indicates centromeres. Each particle equals ...

The study revealed the distinctive Bouquet configuration in both species, where telomeres cluster and centromeres are located at the nuclear periphery, offering vital insights into chromosome ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

The most common abnormalities found were a variety of structural anomalies consisting of chromatid exchanges and chromatid and isochromatid breaks. Chromatid exchanges are abnormal chromosomal ...

The presence of specific anti-nuclear-rim, anti-nuclear-dot or anti-centromere antibodies (or anti-gp210 or sp-100 by ELISA) can frequently be sufficient to diagnose AMA-negative PBC. True ...

Centromeres are composed of condensed and ... it is not known whether centrosomes contain information for driving biased chromatid segregation (see below). Figure 2: Possible links between ...

The CPC can localize to centromeres after partial depletion ... the regulation of sister chromatid cohesion and the completion of cytokinesis are among the crucial mitotic functions that require ...

Specifically, we describe the contributions of intra-chromosomal, inter-homolog, and inter-sister chromatid contacts to genome organization and gene expression. FIGURE 2. Homolog pairing role during ...

Suppression, first observed by Beadle in 1932, dictates that crossovers do not occur in regions surrounding the centromere and telomeres. The mechanisms behind crossover patterning remain largely ...

Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in humans. Here, we identify the ...

In budding yeast, a single cenH3 (Cse4) nucleosome occupies the ∼120-bp functional centromere, however conflicting structural models for the particle have been proposed. To resolve this controversy, ...