Researchers trial inhalable gene therapy for cystic fibrosis, offering a potential breakthrough in treating the genetic lung ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

detection methods using whole genome sequencing data are affected by the measurement scale and parameters, and the breakpoint of CNVs is easily influenced by the sizes of windows in preparing RD ...

Monoclonal T cells from both patients had detectable CAR transgene expression and integration ... T-cell therapy that is produced by means of lentiviral transduction. In the phase 3, randomized ...

State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, No. 72 Binhai Road, Qingdao 266237, P. R. China ...

Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor ... CAR was detected in high abundance in DNA extracted from the patient’s duodenal-biopsy samples ...

In HBeAg(−) patients, the predominant source of HBsAg is HBV DNA integrated in the host cell genome.8 9 Therefore, the lack of correlation between cirB-RNA and serum HBsAg suggests that the cobas HBV ...

Cas9-expressing HT-29 cells were transduced with a lentiviral sgRNA library ... gDNA from cell pellets was isolated using QIAGEN Gentra Puregene kit and genome-integrated sgRNA sequences were ...