Researchers trial inhalable gene therapy for cystic fibrosis, offering a potential breakthrough in treating the genetic lung ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

detection methods using whole genome sequencing data are affected by the measurement scale and parameters, and the breakpoint of CNVs is easily influenced by the sizes of windows in preparing RD ...

Monoclonal T cells from both patients had detectable CAR transgene expression and integration ... T-cell therapy that is produced by means of lentiviral transduction. In the phase 3, randomized ...

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States Center for Diagnostics and Therapeutics, Department of Chemistry, Georgia State University, Atlanta, Georgia ...

State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, No. 72 Binhai Road, Qingdao 266237, P. R. China ...

Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor ... CAR was detected in high abundance in DNA extracted from the patient’s duodenal-biopsy samples ...

Apart from species constraints, these methods have unique advantages and limitations, including random gene integration, low gene transfer efficiency ... Schematic representation biolistic DNA ...