Leptin-sensitive animals showed no such dysregulation. "With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals," Tan says.

However, it has not been shown to be elevated in dietary obese animal models. In a study in mice, TNF-a-induced glycerol and fatty acid release was substantially reduced by a thiazolidinedione.

Leptin-sensitive animals showed no such dysregulation. "With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals," Tan says.

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

Leptin-sensitive animals showed no such dysregulation. “With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals,” Tan says.

Leptin-sensitive animals showed no such dysregulation. “With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals,” Tan says. To ...