POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22 ...

Mitochondria contain their own DNA which requires a specific enzyme to replicate, found in host cell’s POLG and POLG2 genes. Mutations in these genes therefore impact the ability for ...

POLG disease is caused by inherited mutations in the POLG gene—more than 200 disease-causing POLG mutations are known, according to the POLG Foundation. These mutations "compromise the ...

Prince Frederik, the second cousin of the heir to the Luxembourg throne, discovered at age 14 that he had a mutation in his POLG gene, which is involved in the replication and repair of DNA.

It is caused by mutations in the POLG gene that impede mitochondrial DNA’s ability to replicate correctly and deliver energy to cells. The result is “progressive multiple organ dysfunction and ...

He was 22. Frederik died from a rare genetic condition called POLG Mitochondrial disease, his dad announced in a statement shared on the POLG Foundation website. “It is with a very heavy heart ...

It is named for the POLG gene, and there are more than 200 POLG mutations that can cause the disease. The POLG Foundation described the disorder as robbing cells of energy and comparing it to a ...

PolG disease is a genetic disease caused by mutations that occur in the POLG gene in the mitochondria of a person's cell, according to the UMDF. It's one of the most commonly inherited ...