Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer ...

Successful gene therapeutic clinical trials with retroviral vectors Gene therapy ... of the provirus generates an RNA with the same LTR structure as the original RNA. AAA: 3'poly(A) sequence ...

Human endogenous retroviruses that colonized vertebrate DNA millions of ... more intact sequences from HERVs have been linked to disease. Around 8 percent of our genetic code stems from HERVs, the ...

In 1985, his group became the first to solve the structure ... including retroviruses and the Ebola virus. These proteins are responsible for binding and fusing the virus to target cell membranes.

A retrovirus is an infectious agent belonging ... upstream ORFs elicits distinct immune responses and regulates viral gene expression in a DDX3-dependent manner. HIV reservoir dynamics are still ...

Pre-clinical studies indicate that efficient retrovirus-mediated gene transfer into hematopoietic stem cells and progenitor cells can be achieved by co-localizing retroviral particles and target ...

but endogenous retroviruses may well be one or more of the genetic factors in the pathogenesis. As will become apparent in the following, we do not see the endogenous retroviruses as alternatives ...