Jul 31, 2023 · Pneumonia has been defined as an infection of the lung parenchyma. Rather than looking at it as a single disease, health care professionals must remember that pneumonia is an umbrella term for a group of syndromes caused by a variety of organisms resulting in varied manifestations and sequelae.

Here, we review the pathogenesis of pneumonia and acute lung injury, including how respiratory infections and lung injury disrupt lung homoeostasis, and provide an overview of respiratory microbial pathogenesis, the lung microbiome, and interventions that have been demonstrated to improve outcomes—or not—in human clinical trials.

Sep 1, 2020 · Atypical pneumonia: The acute infection caused by a pathogen not detectable by traditional Gram stain or standard cultures. Ventilator-associated pneumonia: VAP is a type of nosocomial infection of lung tissue that usually develops 48 hours or longer after intubation for mechanical ventilation.

Jul 4, 2020 · The pathophysiology of pneumonia is characterized by four stages. The first stage of the disease occurs within 24 hours of infection and it is distinguished by vascular congestion and alveolar edema. The lungs are also invaded by bacteria and few neutrophils. Typical symptoms include: Cough; Fever; Chills; Increased sputum production; Shortness ...

Mar 2, 2022 · Pneumonia is an acute respiratory infection of the lung parenchyma caused by one or co-infecting pathogens. These pathogens cause the lung parenchyma (alveoli) to become inflamed and fill with pus and fluid, limiting oxygen intake and making gas exchange ineffective.

Nov 12, 2024 · Common causes — Streptococcus pneumoniae (pneumococcus) and respiratory viruses are the most frequently detected pathogens in patients with CAP [8,16]. However, in a large proportion of cases (up to 62 percent in some studies performed in hospital settings), no pathogen is detected despite extensive microbiologic evaluation [8,17,18].

Apr 8, 2021 · The pathogenesis of pneumonia has been suggested to include a change in the lung microbiota, from a physiological, homeostatic state to dysbiosis, in association with a low microbial...

While pneumonia results from microbial infection, the pathogenesis of this disease is driven by the host response. Within the host, pneumonia is by definition within the lungs, but it is a complex disease that involves diverse physiological systems working together.

May 27, 2022 · Here, we review the pathogenesis of pneumonia and acute lung injury, including how respiratory infections and lung injury disrupt lung homoeostasis, and provide an overview of respiratory microbial pathogenesis, the lung microbiome, and interventions that have been demonstrated to improve outcomes-or not-in human clinical trials.

May 27, 2022 · Here, we review the pathogenesis of pneumonia and acute lung injury, including how respiratory infections and lung injury disrupt lung homoeostasis, and provide an overview of respiratory microbial pathogenesis, the lung microbiome, and interventions that have been demonstrated to improve outcomes—or not—in human clinical trials.