Jun 2, 2018 · Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life.

Psoriatic arthritis (PsA), a heterogeneous chronic inflammatory immune-mediated disease characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis, and dactylitis), generally occurs in patients with psoriasis. PsA is also associated with uveitis and inflammatory bowel disease (Crohn’s disease and ulcerative colitis).

Jan 7, 2024 · The etiology and pathogenesis of psoriatic arthritis are not fully understood; they involve a complex interaction between genetic and environmental factors, resulting in immune-mediated inflammation involving the skin, joints, and other organs.

The pathogenesis and treatment of this disorder and overviews of the clinical manifestations, diagnosis, and treatment of psoriasis are presented separately. (See "Pathogenesis of psoriatic arthritis" and "Treatment of psoriatic arthritis" and "Psoriasis: Epidemiology, clinical manifestations, and diagnosis" and "Chronic plaque psoriasis in ...

Mar 3, 2023 · The pathogenesis of PsA is complex and multifaceted, with an interplay of genetic predisposition, triggering environmental factors, and activation of the innate and adaptive immune system, although autoinflammation has also been implicated.

Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life.

Psoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psoriatic arthritis, research has identified ...

Dendritic cells (DC) play a central role in the pathogenesis of psoriatic arthritis. DC activated by different stimuli produce and secrete IL-23 and IL-12 which further stimulate Th17, γδT cells and ILC3 and Th1 cells, respectively, leading to the production of inflammatory cytokines.

The pathogenesis of psoriatic arthritis (PsA) is complex and likely to be closely related to the mechanisms that underlie psoriasis. Joint and bone changes have features of both spondyloarthritis and rheumatoid arthritis as well.

Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of efective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life.