Also transcribed are the two rRNAs and 22 tRNAs required for mitochondrial translation. This process is accomplished, with the help of several accessory proteins, by the human …

Sep 6, 2018 · The crystal structure of human mitochondrial RNA polymerase demonstrates a resemblance to phage RNAPs and highlights differences that may explain factor dependence …

Sep 25, 2011 · Here we report the X-ray structure of human mtRNAP at 2.5 Å resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain that remotely …

Oct 2, 2023 · Mitochondrial transcription is performed by the single-subunit, mitochondrial RNA polymerase (POLRMT), which is related to the T7 bacteriophage RNA polymerase (T7 RNAP) 6.

TFAM and mitochondrial RNA processing enzymes are target genes of NRF1, and TFBM1 and TFBM2 were also recently demonstrated to be their target. These two proteins enhance …

Among other nucleoid core factors, one can distinguish mtDNA polymerase γ (POLG), mitochondrial single-stranded DNA-binding protein (mtSSB), the NAD-dependent protein …

The human mitochondrial RNA polymerase (h-mtRNAP) serves as both the transcriptase for expression and the primase for replication of mitochondrial DNA. As such, the enzyme is of …

Sep 1, 2012 · The human mitochondrial RNA polymerase (POLRMT) transcribes the mitochondrial genome with the help of accessory factors. POLRMT is evolutionarily related to …

Sep 25, 2011 · Here we report the X-ray structure of human mtRNAP at 2.5 Å resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain that remotely …

Sep 1, 2012 · Mitochondrial polyadenylation regulates RNA function and metabolism. Mitochondrial polyadenylation occurs in higher eukaryotes. Human mitochondrial poly(A) …