
Human mitochondrial RNA polymerase: structure-function
Also transcribed are the two rRNAs and 22 tRNAs required for mitochondrial translation. This process is accomplished, with the help of several accessory proteins, by the human …
Structural basis of mitochondrial transcription - Nature
Sep 6, 2018 · The crystal structure of human mitochondrial RNA polymerase demonstrates a resemblance to phage RNAPs and highlights differences that may explain factor dependence …
Structure of human mitochondrial RNA polymerase | Nature
Sep 25, 2011 · Here we report the X-ray structure of human mtRNAP at 2.5 Å resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain that remotely …
Mechanisms and regulation of human mitochondrial transcription
Oct 2, 2023 · Mitochondrial transcription is performed by the single-subunit, mitochondrial RNA polymerase (POLRMT), which is related to the T7 bacteriophage RNA polymerase (T7 RNAP) 6.
Transcription, Processing, and Decay of Mitochondrial RNA in …
TFAM and mitochondrial RNA processing enzymes are target genes of NRF1, and TFBM1 and TFBM2 were also recently demonstrated to be their target. These two proteins enhance …
Human Mitochondrial RNA Processing and Modifications: Overview
Among other nucleoid core factors, one can distinguish mtDNA polymerase γ (POLG), mitochondrial single-stranded DNA-binding protein (mtSSB), the NAD-dependent protein …
Human Mitochondrial RNA Polymerase: Evaluation of the …
The human mitochondrial RNA polymerase (h-mtRNAP) serves as both the transcriptase for expression and the primase for replication of mitochondrial DNA. As such, the enzyme is of …
Human mitochondrial RNA polymerase: Structure–function, …
Sep 1, 2012 · The human mitochondrial RNA polymerase (POLRMT) transcribes the mitochondrial genome with the help of accessory factors. POLRMT is evolutionarily related to …
Structure of human mitochondrial RNA polymerase - PubMed
Sep 25, 2011 · Here we report the X-ray structure of human mtRNAP at 2.5 Å resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain that remotely …
Mitochondrial poly(A) polymerase and polyadenylation
Sep 1, 2012 · Mitochondrial polyadenylation regulates RNA function and metabolism. Mitochondrial polyadenylation occurs in higher eukaryotes. Human mitochondrial poly(A) …
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